Sample Report: https://gdx.net/core/sample-reports/gi-effects-2200-sample-report.pdf
 
A Commensal Balance Infographic – Designed to provide a more precise view of an individual patient's commensal bacteria (PCR) results relative to a spectrum of healthy and unhealthy commensal patterns. It is a composite of two measures:
The Healthy-Pattern Continuum (formerly known as the Diversity Association Index) is a progressive ranking scale based on a Genova proprietary algorithm that differentiates healthy and unhealthy commensal patterns. This algorithm is applied to an individual patient's GI Effects commensal bacteria (PCR) findings, and produces a numeric result ranging from 0 to 10. It is denoted by the 'y' axis of the Commensal Balance infographic.
The Reference Variance Score reflects the total number of an individual patient's commensal bacteria (PCR) results that are out of reference range. This number ranges from zero to 24, and is denoted by the 'x' axis of the Commensal Balance infographic.
Clinical Association Charts – See how patient results compare to commensal bacteria (PCR) and biomarker patterns seen in patients with specific clinical conditions:
IBS
IBD
Metabolic Syndrome
Chronic Fatigue
Autoimmune dysfunction
Type 2 Diabetes
High Blood Pressure
Mood Disorders
 
Clinical Overview
When Should the GI Effects Comprehensive Stool Profile Be Considered?
The GI Effects Comprehensive Stool Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. This stool analysis utilizes biomarkers such as Calprotectin to differentiate between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). In addition, Genova's GI Effects test can be used to evaluate patients with a clinical history that suggests a gastrointestinal infection or dysbiosis.
Gut microbes are codependent with one another and with their human host, and the health of one affects the other. A sizeable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract. The diverse metabolic activities of the microbiome ultimately impact the human host, and the activities of the human host ultimately affect the health of their microbiome.
What is the GI Effects Comprehensive Stool Profile?
The GI Effects® Comprehensive Stool Profile is an advanced stool test that provides immediate, actionable clinical information for the management of gastrointestinal health. Utilizing cutting-edge technologies and biomarkers, this test offers valuable insight into digestive function, intestinal inflammation, and the intestinal microbiome.
The biomarkers from the GI Effects Comprehensive Profile are reported using the DIG framework, providing key clinical information for three main gastrointestinal functional areas:
Digestion/Absorption:
Pancreatic Elastase-1 is a marker of exocrine pancreatic function.
Products of Protein Breakdown are markers of undigested protein reaching the colon.
Fecal Fat is a marker of fat breakdown and absorption.
Inflammation/Immunology:
Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).3,4
Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.
Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.
Gut Microbiome:
Metabolic indicators, including short-chain fatty acids and beta-glucuronidase, demonstrate specific and vital metabolic functions performed by the microbiota.
Commensal Bacteria demonstrate the composition and relative abundance of gut organisms.
More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques.
GI Effects assesses a set of 24 genera/species that map to 7 major phyla.
Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.
Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic organisms that have been cultured. The report includes effective prescriptive and natural agents.
Parasitology
GI Effects provides microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
Enzyme immunoassay (EIA), widely recognized for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia.
Selection of a one-day or three-day sample collection is based on clinician's clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.
What Advantage Does the Profile Offer Compared to Other Diagnostics?
A structured fecal biomarker panel offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea could stem from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism. A positive result on one or more fecal biomarker tests may guide therapy, either by suggesting a treatable alternative diagnosis or by eliminating a diagnosis from further consideration. The latter allows individualized targeted treatment to be redirected to more likely diagnoses.5,6
GI Effects® represents the best technical platform to assess gut health, including an anaerobic bacteria PCR molecular assay, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for cultivable species identification, as well as stool-based biomarkers for gastrointestinal diagnostics.
The test report is organized so that the clinician may move through results in a logical order that enhances clinical utility, starting with innovative Interpretation-At-A-Glance pages to synthesize the information.
What Can Clinicians and Patients Expect from GI EffectsComprehensive Profile Stool Testing?
The GI Effects Stool Profile biomarkers provide comprehensive information for the development of strategic interventions. Symptoms often improve as identified functional imbalances and inadequacies become normalized through targeted dietary, lifestyle, and supplementation therapeutics.
The GI Effects Interpretive Guide is a convenient tool to support the therapeutic decision-making process for patients with complex gut-related conditions.